We conducted a prospective, observational clinical validation study to assess the diagnostic accuracy of the AI algorithm (ADAE) in predicting melanoma from dermoscopy skin lesion images. Patients who had consented for a skin biopsy to exclude melanoma were eligible. All lesions underwent biopsy.
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "11.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8668119", "mel_class": "invasive melanoma", "mel_thick_mm": "0.30", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_8489445", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0235712", "melanocytic": true, "patient_id": "IP_8566965", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "10.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_1774294", "melanocytic": true, "patient_id": "IP_8209756", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "dermatofibroma", "diagnosis_1": "Benign", "diagnosis_2": "Benign soft tissue proliferations - Fibro-histiocytic", "diagnosis_3": "Dermatofibroma", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0135315", "melanocytic": false, "patient_id": "IP_6970316", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 242, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "10.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Collision - Only benign proliferations", "diagnosis_3": null, "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_1833437", "melanocytic": true, "patient_id": "IP_7717848", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 2068, "age_approx": 30, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "2.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5463461", "melanocytic": true, "patient_id": "IP_6098503", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 2068, "age_approx": 30, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9685250", "melanocytic": true, "patient_id": "IP_6098503", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 244, "age_approx": 75, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9198580", "melanocytic": true, "patient_id": "IP_1764181", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 244, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9524520", "melanocytic": true, "patient_id": "IP_1764181", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_0175063", "melanocytic": false, "patient_id": "IP_9624374", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.40", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9853659", "melanocytic": true, "patient_id": "IP_1988953", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "anterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "8.60", "concomitant_biopsy": true, "dermoscopic_type": "contact non-polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7203080", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_1988953", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.30", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2233573", "melanocytic": true, "patient_id": "IP_8489106", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.40", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5950317", "melanocytic": true, "patient_id": "IP_8489106", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 2693, "age_approx": 70, "anatom_site_general": "head/neck", "benign_malignant": "malignant", "clin_size_long_diam_mm": "5.40", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_4758821", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_5748247", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "9.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_3665493", "melanocytic": true, "patient_id": "IP_5912408", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1233, "age_approx": 80, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "10.40", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8558961", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_1999627", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5486717", "melanocytic": true, "patient_id": "IP_0770240", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7333948", "melanocytic": true, "patient_id": "IP_0770240", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 6477, "age_approx": 75, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.30", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5262136", "melanocytic": true, "patient_id": "IP_2248025", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1049, "age_approx": 80, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "9.80", "concomitant_biopsy": true, "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8742309", "melanocytic": true, "patient_id": "IP_0541183", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8608695", "melanocytic": true, "patient_id": "IP_0583992", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4982960", "melanocytic": true, "patient_id": "IP_0583992", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "17.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5513286", "melanocytic": true, "patient_id": "IP_4421863", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "atypical melanocytic proliferation", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate melanocytic proliferations", "diagnosis_3": "Atypical melanocytic neoplasm", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_9608650", "melanocytic": true, "patient_id": "IP_2279622", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "palms/soles", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3129676", "melanocytic": true, "patient_id": "IP_9131471", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.00", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7612768", "melanocytic": true, "patient_id": "IP_3531969", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "lower extremity", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "5.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "atypical melanocytic proliferation", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate melanocytic proliferations", "diagnosis_3": "Atypical melanocytic neoplasm", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4432312", "melanocytic": true, "patient_id": "IP_0395589", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.70", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0627663", "melanocytic": true, "patient_id": "IP_3128864", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.00", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_4": null, "diagnosis_5": null, "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9620902", "melanocytic": true, "patient_id": "IP_2711304", "personal_hx_mm": false, "sex": "female" }