We conducted a prospective, observational clinical validation study to assess the diagnostic accuracy of the AI algorithm (ADAE) in predicting melanoma from dermoscopy skin lesion images. Patients who had consented for a skin biopsy to exclude melanoma were eligible. All lesions underwent biopsy.
{ "acquisition_day": 1, "age_approx": 30, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0993009", "melanocytic": true, "patient_id": "IP_4889205", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1639, "age_approx": 65, "anatom_site_general": "lower extremity", "benign_malignant": "indeterminate/malignant", "clin_size_long_diam_mm": "8.70", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7149631", "mel_class": "invasive melanoma", "mel_thick_mm": "0.35", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_1885773", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "10.40", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0186109", "mel_class": "invasive melanoma", "mel_thick_mm": "0.40", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_3096889", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 169, "age_approx": 75, "anatom_site_general": "anterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "9.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "squamous cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Collision - At least one malignant proliferation", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9476050", "melanocytic": false, "patient_id": "IP_5951155", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 169, "age_approx": 75, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_1737724", "melanocytic": true, "patient_id": "IP_5951155", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.60", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7372235", "melanocytic": true, "patient_id": "IP_6559812", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Combined", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0284712", "melanocytic": true, "nevus_type": "combined", "patient_id": "IP_6559812", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "19.10", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2195048", "mel_class": "invasive melanoma", "mel_thick_mm": "7.30", "mel_ulcer": true, "melanocytic": true, "patient_id": "IP_9975461", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "IV", "image_type": "dermoscopic", "lesion_id": "IL_2163230", "melanocytic": true, "patient_id": "IP_4898553", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "9.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_7147881", "melanocytic": true, "patient_id": "IP_9246199", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "posterior torso", "benign_malignant": "indeterminate/malignant", "clin_size_long_diam_mm": "9.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1654889", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_8166166", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.90", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_7803497", "melanocytic": false, "patient_id": "IP_1851850", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "14.50", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0646973", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_7250001", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 106, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "9.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5747393", "melanocytic": true, "patient_id": "IP_9485229", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_3339854", "melanocytic": true, "patient_id": "IP_6988706", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_0501915", "melanocytic": true, "patient_id": "IP_6988706", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "1.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_9958209", "melanocytic": true, "patient_id": "IP_4509193", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2273638", "melanocytic": true, "patient_id": "IP_4509193", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "11.20", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "IV", "image_type": "dermoscopic", "lesion_id": "IL_2983456", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_6569660", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "2.70", "concomitant_biopsy": true, "dermoscopic_type": "contact non-polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5357425", "melanocytic": true, "patient_id": "IP_6178092", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "2.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_3535056", "melanocytic": true, "patient_id": "IP_0831054", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2154732", "melanocytic": true, "patient_id": "IP_3068702", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1701366", "melanocytic": true, "patient_id": "IP_3068702", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_5674392", "melanocytic": true, "patient_id": "IP_3068702", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 198, "age_approx": 80, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "2.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_0641149", "melanocytic": true, "patient_id": "IP_5789947", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 198, "age_approx": 80, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_7204597", "melanocytic": true, "patient_id": "IP_5789947", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "17.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2031685", "melanocytic": true, "patient_id": "IP_9194333", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 195, "age_approx": 65, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2210421", "melanocytic": true, "patient_id": "IP_2712283", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 195, "age_approx": 65, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1028266", "melanocytic": true, "patient_id": "IP_2712283", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 195, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Collision - Only benign proliferations", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2298841", "melanocytic": true, "patient_id": "IP_2712283", "personal_hx_mm": false, "sex": "male" }