We conducted a prospective, observational clinical validation study to assess the diagnostic accuracy of the AI algorithm (ADAE) in predicting melanoma from dermoscopy skin lesion images. Patients who had consented for a skin biopsy to exclude melanoma were eligible. All lesions underwent biopsy.
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_1839262", "melanocytic": true, "patient_id": "IP_3516181", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_7795752", "melanocytic": true, "patient_id": "IP_8634652", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "9.00", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "squamous cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Collision - At least one malignant proliferation", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_9132518", "melanocytic": false, "patient_id": "IP_7164821", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0227400", "melanocytic": true, "patient_id": "IP_6953199", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "3.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8956171", "mel_class": "invasive melanoma", "mel_thick_mm": "0.20", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_7819499", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "10.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_6412416", "melanocytic": true, "patient_id": "IP_7412246", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "5.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_9545123", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_6270741", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_4663727", "melanocytic": true, "patient_id": "IP_7015662", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "9.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_5686070", "melanocytic": false, "patient_id": "IP_7015662", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_5109283", "melanocytic": true, "patient_id": "IP_4377460", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "6.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "basal cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant adnexal epithelial proliferations - Follicular", "diagnosis_3": "Basal cell carcinoma", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2165341", "melanocytic": false, "patient_id": "IP_9919430", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0207007", "melanocytic": true, "patient_id": "IP_9919430", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "head/neck", "benign_malignant": "malignant", "clin_size_long_diam_mm": "5.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0641511", "mel_class": "invasive melanoma", "mel_thick_mm": "0.40", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_8200450", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9115140", "melanocytic": false, "patient_id": "IP_0933539", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_6228942", "melanocytic": true, "patient_id": "IP_9442934", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "upper extremity", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "6.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "atypical melanocytic proliferation", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate melanocytic proliferations", "diagnosis_3": "Atypical melanocytic neoplasm", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9486656", "melanocytic": true, "patient_id": "IP_9442934", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 25, "anatom_site_general": "posterior torso", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "5.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_6582114", "melanocytic": true, "patient_id": "IP_7349538", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 2619, "age_approx": 25, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "10.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7579521", "melanocytic": true, "patient_id": "IP_8041141", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.90", "concomitant_biopsy": true, "diagnosis": "dermatofibroma", "diagnosis_1": "Benign", "diagnosis_2": "Benign soft tissue proliferations - Fibro-histiocytic", "diagnosis_3": "Dermatofibroma", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "IV", "image_type": "dermoscopic", "lesion_id": "IL_0294036", "melanocytic": false, "patient_id": "IP_4854139", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "8.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8141258", "mel_class": "invasive melanoma", "mel_thick_mm": "0.40", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_3067207", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 892, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_9662458", "melanocytic": true, "patient_id": "IP_6624700", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "12.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0978187", "mel_class": "melanoma in situ", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_8096012", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "head/neck", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "8.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "atypical melanocytic proliferation", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate melanocytic proliferations", "diagnosis_3": "Atypical melanocytic neoplasm", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4545733", "melanocytic": true, "patient_id": "IP_4297780", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_0928162", "melanocytic": true, "patient_id": "IP_3266584", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4821694", "melanocytic": true, "patient_id": "IP_5436066", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "anterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "10.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_1700773", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_2850340", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 30, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0523579", "melanocytic": true, "patient_id": "IP_2236806", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 30, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7846093", "melanocytic": true, "patient_id": "IP_2236806", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "20.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3219644", "mel_class": "invasive melanoma", "mel_thick_mm": "0.50", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_5086285", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "upper extremity", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "4.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "atypical melanocytic proliferation", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate melanocytic proliferations", "diagnosis_3": "Atypical melanocytic neoplasm", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4744411", "melanocytic": true, "patient_id": "IP_3510706", "personal_hx_mm": false, "sex": "female" }