We conducted a prospective, observational clinical validation study to assess the diagnostic accuracy of the AI algorithm (ADAE) in predicting melanoma from dermoscopy skin lesion images. Patients who had consented for a skin biopsy to exclude melanoma were eligible. All lesions underwent biopsy.
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0460513", "melanocytic": false, "patient_id": "IP_3039884", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "11.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7575801", "melanocytic": true, "patient_id": "IP_3039884", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "4.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5619757", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_5864933", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_9964669", "melanocytic": true, "patient_id": "IP_5737852", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_8471027", "melanocytic": true, "patient_id": "IP_5737852", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 99, "age_approx": 70, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "14.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_3695511", "melanocytic": false, "patient_id": "IP_6575300", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 124, "age_approx": 70, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.60", "concomitant_biopsy": true, "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0036242", "melanocytic": true, "patient_id": "IP_7717848", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 124, "age_approx": 70, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "8.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2725316", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_7717848", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 124, "age_approx": 70, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "10.40", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7286719", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_7717848", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3609360", "melanocytic": true, "patient_id": "IP_8193249", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8539789", "melanocytic": true, "patient_id": "IP_8193249", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2039794", "melanocytic": true, "patient_id": "IP_0699267", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "5.90", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_5645403", "mel_class": "invasive melanoma", "mel_thick_mm": "0.25", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_1638966", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1121, "age_approx": 80, "anatom_site_general": "anterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "10.10", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2070313", "mel_class": "invasive melanoma", "mel_thick_mm": "0.50", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_1999627", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_5255630", "melanocytic": true, "patient_id": "IP_2963926", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 20, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_6733891", "melanocytic": true, "patient_id": "IP_3778684", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "4.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_3568556", "mel_class": "invasive melanoma", "mel_thick_mm": "0.30", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_7915407", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Collision - Only benign proliferations", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7491775", "melanocytic": true, "patient_id": "IP_9227859", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9511996", "melanocytic": true, "patient_id": "IP_3919700", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1736, "age_approx": 30, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7567811", "melanocytic": true, "patient_id": "IP_4938382", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_4777158", "melanocytic": true, "patient_id": "IP_3235031", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2907315", "melanocytic": true, "patient_id": "IP_1924080", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "lateral torso", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "11.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "atypical melanocytic proliferation", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate melanocytic proliferations", "diagnosis_3": "Atypical melanocytic neoplasm", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_7912497", "melanocytic": true, "patient_id": "IP_5532748", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_9322032", "melanocytic": true, "patient_id": "IP_8286761", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 30, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3135227", "melanocytic": true, "patient_id": "IP_7452604", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 30, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "2.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_1057208", "melanocytic": true, "patient_id": "IP_7452604", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 20, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "9.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7816327", "melanocytic": true, "patient_id": "IP_7919791", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 25, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4524875", "melanocytic": true, "patient_id": "IP_5102067", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 25, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2480011", "melanocytic": true, "patient_id": "IP_5102067", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 25, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8064701", "melanocytic": true, "patient_id": "IP_5102067", "personal_hx_mm": false, "sex": "female" }