We conducted a prospective, observational clinical validation study to assess the diagnostic accuracy of the AI algorithm (ADAE) in predicting melanoma from dermoscopy skin lesion images. Patients who had consented for a skin biopsy to exclude melanoma were eligible. All lesions underwent biopsy.
{ "acquisition_day": 1, "age_approx": 25, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_6609512", "melanocytic": true, "patient_id": "IP_3158554", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "5.60", "concomitant_biopsy": true, "diagnosis": "squamous cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant epidermal proliferations", "diagnosis_3": "Squamous cell carcinoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_6091150", "melanocytic": false, "patient_id": "IP_9890421", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_7583140", "melanocytic": true, "patient_id": "IP_3734488", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2962194", "melanocytic": true, "patient_id": "IP_6975468", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_3694051", "melanocytic": false, "patient_id": "IP_6975468", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1090434", "melanocytic": false, "patient_id": "IP_7894934", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_4490560", "melanocytic": true, "patient_id": "IP_7894934", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Collision - Only benign proliferations", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1434222", "melanocytic": true, "patient_id": "IP_5124329", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.40", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_4585051", "melanocytic": true, "patient_id": "IP_7525385", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9130134", "melanocytic": true, "patient_id": "IP_6250739", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Collision - Only benign proliferations", "diagnosis_confirm_type": "histopathology", "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2960154", "melanocytic": true, "patient_id": "IP_2829259", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_0465154", "melanocytic": true, "patient_id": "IP_2829259", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.30", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5428644", "melanocytic": true, "patient_id": "IP_0599018", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "head/neck", "benign_malignant": "malignant", "clin_size_long_diam_mm": "5.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8640252", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_0599018", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "concomitant_biopsy": true, "diagnosis": "squamous cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant epidermal proliferations", "diagnosis_3": "Squamous cell carcinoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7696412", "melanocytic": false, "patient_id": "IP_8153140", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "10.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Blue nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "IV", "image_type": "dermoscopic", "lesion_id": "IL_6540811", "melanocytic": true, "nevus_type": "blue", "patient_id": "IP_7067884", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2103677", "melanocytic": false, "patient_id": "IP_3520387", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "10.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_8030216", "mel_class": "invasive melanoma", "mel_thick_mm": "0.30", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_6575300", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "12.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_1338869", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_6575300", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3092267", "melanocytic": true, "patient_id": "IP_8948648", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 2820, "age_approx": 50, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_6234421", "melanocytic": true, "patient_id": "IP_2360609", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_1404959", "melanocytic": true, "patient_id": "IP_1400932", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "clear cell acanthoma", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Clear cell acanthoma", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9900492", "melanocytic": false, "patient_id": "IP_5951155", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "12.20", "concomitant_biopsy": true, "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7016662", "melanocytic": false, "patient_id": "IP_5951155", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3007728", "melanocytic": false, "patient_id": "IP_5951155", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 30, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.40", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1327294", "melanocytic": true, "patient_id": "IP_2520256", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "verruca", "diagnosis_1": "Benign", "diagnosis_2": "Inflammatory or infectious diseases", "diagnosis_3": "Verruca", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_5948503", "melanocytic": false, "patient_id": "IP_5415710", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "4.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "atypical melanocytic proliferation", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate melanocytic proliferations", "diagnosis_3": "Atypical melanocytic neoplasm", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1776283", "melanocytic": true, "patient_id": "IP_9429205", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_6849070", "melanocytic": true, "patient_id": "IP_5333319", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4460385", "melanocytic": false, "patient_id": "IP_3313829", "personal_hx_mm": false, "sex": "male" }