We conducted a prospective, observational clinical validation study to assess the diagnostic accuracy of the AI algorithm (ADAE) in predicting melanoma from dermoscopy skin lesion images. Patients who had consented for a skin biopsy to exclude melanoma were eligible. All lesions underwent biopsy.
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "17.50", "concomitant_biopsy": true, "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3684548", "melanocytic": false, "patient_id": "IP_3313829", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "head/neck", "benign_malignant": "malignant", "clin_size_long_diam_mm": "9.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "squamous cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant epidermal proliferations", "diagnosis_3": "Squamous cell carcinoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4039710", "melanocytic": false, "patient_id": "IP_9989989", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_7589780", "melanocytic": true, "patient_id": "IP_3265003", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_6510267", "melanocytic": true, "patient_id": "IP_5786579", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "3.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "squamous cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Collision - At least one malignant proliferation", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5089954", "melanocytic": false, "patient_id": "IP_7817060", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.40", "concomitant_biopsy": true, "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0053538", "melanocytic": false, "patient_id": "IP_7817060", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "13.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "basal cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant adnexal epithelial proliferations - Follicular", "diagnosis_3": "Basal cell carcinoma", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2317568", "melanocytic": false, "patient_id": "IP_3987348", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1113358", "melanocytic": true, "patient_id": "IP_9383306", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "6.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7347014", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_6723298", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 35, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.60", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7550272", "melanocytic": true, "patient_id": "IP_9278714", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 40, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "4.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5852213", "mel_class": "invasive melanoma", "mel_thick_mm": "0.40", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_0916785", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Collision - Only benign proliferations", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3978832", "melanocytic": true, "patient_id": "IP_9534366", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8448467", "melanocytic": false, "patient_id": "IP_7386868", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 85, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1932005", "melanocytic": false, "patient_id": "IP_4245895", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 85, "anatom_site_general": "upper extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "4.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "squamous cell carcinoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant epidermal proliferations", "diagnosis_3": "Squamous cell carcinoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_2996668", "melanocytic": false, "patient_id": "IP_4245895", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_6643611", "melanocytic": true, "patient_id": "IP_7205082", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "anterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "7.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_0346398", "mel_class": "invasive melanoma", "mel_thick_mm": "0.45", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_4853824", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_4734846", "melanocytic": true, "patient_id": "IP_0385393", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "12.60", "concomitant_biopsy": true, "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9134111", "melanocytic": true, "patient_id": "IP_6575373", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8129390", "melanocytic": true, "patient_id": "IP_5276820", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.40", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7540024", "melanocytic": true, "patient_id": "IP_8219510", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_1541362", "melanocytic": true, "patient_id": "IP_3891138", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "posterior torso", "benign_malignant": "malignant", "clin_size_long_diam_mm": "5.80", "concomitant_biopsy": true, "dermoscopic_type": "contact non-polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_5851272", "mel_class": "invasive melanoma", "mel_thick_mm": "0.35", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_3889950", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_1853192", "melanocytic": true, "patient_id": "IP_5711377", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 25, "anatom_site_general": "palms/soles", "anatom_site_special": "acral palms or soles", "benign_malignant": "benign", "clin_size_long_diam_mm": "1.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_5852238", "melanocytic": true, "patient_id": "IP_4468352", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 25, "anatom_site_general": "palms/soles", "anatom_site_special": "acral palms or soles", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.50", "concomitant_biopsy": true, "dermoscopic_type": "contact non-polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_6130991", "melanocytic": true, "patient_id": "IP_4468352", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "8.30", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_4337665", "melanocytic": true, "patient_id": "IP_4665602", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 45, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2321832", "melanocytic": true, "patient_id": "IP_5369571", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "6.80", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma Invasive", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_6009276", "mel_class": "invasive melanoma", "mel_thick_mm": "0.30", "mel_ulcer": false, "melanocytic": true, "patient_id": "IP_3028432", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "7.80", "concomitant_biopsy": true, "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_1696242", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_3813847", "personal_hx_mm": true, "sex": "female" }