We conducted a prospective, observational clinical validation study to assess the diagnostic accuracy of the AI algorithm (ADAE) in predicting melanoma from dermoscopy skin lesion images. Patients who had consented for a skin biopsy to exclude melanoma were eligible. All lesions underwent biopsy.
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "1.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_3070677", "melanocytic": true, "patient_id": "IP_4875634", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 30, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "9.40", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7263325", "melanocytic": true, "patient_id": "IP_1532145", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0601715", "melanocytic": true, "patient_id": "IP_4950891", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "11.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_9484535", "melanocytic": true, "patient_id": "IP_6489650", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "4.00", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8100011", "melanocytic": true, "patient_id": "IP_7308167", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "7.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_1459337", "melanocytic": true, "patient_id": "IP_7308167", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 2497, "age_approx": 55, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "IV", "image_type": "dermoscopic", "lesion_id": "IL_3480492", "melanocytic": true, "patient_id": "IP_9563768", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_0011993", "melanocytic": true, "patient_id": "IP_0486641", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 60, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5384691", "melanocytic": true, "patient_id": "IP_6936307", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2414417", "melanocytic": true, "patient_id": "IP_6200159", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9595538", "melanocytic": true, "patient_id": "IP_6200159", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "head/neck", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "9.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "atypical melanocytic proliferation", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate melanocytic proliferations", "diagnosis_3": "Atypical melanocytic neoplasm", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7890160", "melanocytic": true, "patient_id": "IP_6200159", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 70, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Collision - Only benign proliferations", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5244140", "melanocytic": true, "patient_id": "IP_6200159", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "2.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_8073737", "melanocytic": false, "patient_id": "IP_7974093", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "2.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Recurrent or persistent", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2358906", "melanocytic": true, "nevus_type": "persistent/recurrent", "patient_id": "IP_5980386", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "10.80", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_2163165", "melanocytic": false, "patient_id": "IP_5980386", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "2.30", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7597334", "melanocytic": true, "patient_id": "IP_5980386", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 55, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7343446", "melanocytic": false, "patient_id": "IP_9728476", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 50, "anatom_site_general": "head/neck", "benign_malignant": "benign", "clin_size_long_diam_mm": "1.60", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Combined", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_6153654", "melanocytic": true, "nevus_type": "combined", "patient_id": "IP_6751477", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "5.50", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "seborrheic keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Seborrheic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7946649", "melanocytic": false, "patient_id": "IP_3210575", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.10", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7998179", "melanocytic": false, "patient_id": "IP_3210575", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 80, "anatom_site_general": "lower extremity", "benign_malignant": "malignant", "clin_size_long_diam_mm": "8.50", "concomitant_biopsy": true, "dermoscopic_type": "non-contact polarized", "diagnosis": "melanoma", "diagnosis_1": "Malignant", "diagnosis_2": "Malignant melanocytic proliferations (Melanoma)", "diagnosis_3": "Melanoma in situ", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "I", "image_type": "dermoscopic", "lesion_id": "IL_7629517", "mel_class": "melanoma in situ", "melanocytic": true, "patient_id": "IP_8090593", "personal_hx_mm": true, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "posterior torso", "benign_malignant": "indeterminate/benign", "clin_size_long_diam_mm": "9.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_5103863", "melanocytic": true, "patient_id": "IP_7026588", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 65, "anatom_site_general": "lateral torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "6.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": false, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_3337396", "melanocytic": true, "patient_id": "IP_7026588", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "posterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.10", "concomitant_biopsy": true, "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Benign melanocytic proliferations", "diagnosis_3": "Nevus", "diagnosis_4": "Nevus, Atypical, Dysplastic, or Clark", "diagnosis_5": "Nevus, Atypical", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_4893716", "melanocytic": true, "patient_id": "IP_6893721", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.90", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "III", "image_type": "dermoscopic", "lesion_id": "IL_5805814", "melanocytic": true, "patient_id": "IP_6893721", "personal_hx_mm": false, "sex": "female" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "upper extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.20", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "actinic keratosis", "diagnosis_1": "Indeterminate", "diagnosis_2": "Indeterminate epidermal proliferations", "diagnosis_3": "Solar or actinic keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_3747590", "melanocytic": false, "patient_id": "IP_1795359", "personal_hx_mm": false, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "3.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lentigo NOS", "diagnosis_1": "Benign", "diagnosis_2": "Flat melanotic pigmentations - not melanocytic nevus", "diagnosis_3": "Lentigo NOS", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_5186389", "melanocytic": true, "patient_id": "IP_3792900", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "lower extremity", "benign_malignant": "benign", "clin_size_long_diam_mm": "4.70", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "nevus", "diagnosis_1": "Benign", "diagnosis_2": "Collision - Only benign proliferations", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_9183314", "melanocytic": true, "patient_id": "IP_3792900", "personal_hx_mm": true, "sex": "male" }
{ "acquisition_day": 1, "age_approx": 75, "anatom_site_general": "anterior torso", "benign_malignant": "benign", "clin_size_long_diam_mm": "7.30", "concomitant_biopsy": true, "dermoscopic_type": "contact polarized", "diagnosis": "lichenoid keratosis", "diagnosis_1": "Benign", "diagnosis_2": "Benign epidermal proliferations", "diagnosis_3": "Lichen planus like keratosis", "diagnosis_confirm_type": "histopathology", "family_hx_mm": true, "fitzpatrick_skin_type": "II", "image_type": "dermoscopic", "lesion_id": "IL_7754745", "melanocytic": false, "patient_id": "IP_3792900", "personal_hx_mm": true, "sex": "male" }